Uses of Dexamethasone along with Lenalidomide


Multiple myeloma means the excess and abnormal production of Plasma cells in the bone marrow. This disease causes a decreased level of immunoglobulin level. 

Lenalidomide for multiple myeloma is an immunomodulating drug that has an antitumor and anti-inflammatory effect. It works by triggering the apoptosis of drug-resistant multiple Myeloma cells and by inhibiting the binding of multiple Myeloma cells to bone marrow. 

Dexamethasone is a corticosteroid drug that is used for the treatment of relapsed multiple myeloma. It works by inhibiting the white blood cell from cancerous Myeloma cells to other parts of the body leading to a reduction in swelling and inflammation in the body.

Lenalidomide 25 mg along with dexamethasone have more important anti-multiple myeloma properties. This combined drug is approved by the FDA for multiple myeloma relapsing therapy after prior therapy. This combination of drugs improves the extent of response and overall survival rate.


Some common side effects of this combined drug are:

  • Neutropenia

  • Diarrhea

  • Anemia 

  • Pyrexia

  • Muscle pain

  • Constipation

  • Back pain

  • Nausea

  • Peripheral edema

  • Bodyache

  • Dizziness

  • Dyspnea

  • Rash

  • Tremor

  • Thrombocytopenia

Few severe adverse reactions of this combined drug include:

  • Hypersensitivity 

  • Angioedema

  • Epidermal necrolysis

  • Tumor lysis syndrome

  • Tumor flare reactions

  • Hepatotoxicity

  • Second primary malignancies


Recommended Dosage: The recommended initial dose of lenalidomide is 25 mg, which should be taken orally once in a day on Days 1 to 21 of repeated 28-day cycles along with the dexamethasone. For such patients who are aged over 75 years, the initial dexamethasone dose may be reduced. 
Treatment needs to be carried on until disease progression or unacceptable toxicity. 
In those patients who're not candidates for the auto-HSCT, treatment needs to be carried on until disease progression or unacceptable toxicity. For those patients who're candidates for auto-HSCT, hematopoietic stem cell mobilization appears within 4-cycles of a lenalidomide-containing therapy. 


NOTE: The piece of information mentioned about "Uses of Dexamethasone along with Lenalidomide" in this article is just for informational purposes and is not served as a substitute for medical treatment, consultation, diagnosis of an experienced or qualified healthcare professional. 

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